|Other Names||Solute carrier family 22 member 16, Carnitine transporter 2, CT2, Fly-like putative transporter 2, FLIPT2, Flipt 2, Organic cation transporter OKB1, Organic cation/carnitine transporter 6, SLC22A16, OCT6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis|
|Tissue Location||Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.|
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Provided below are standard protocols that you may find useful for product applications.
Organic ion transporters, such as SLC22A16, transportvarious medically and physiologically important compounds,including pharmaceuticals, toxins, hormones, neurotransmitters, andcellular metabolites. These transporters are also referred to asamphiphilic solute facilitators (ASFs).
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Bray, J., et al. Br. J. Cancer 102(6):1003-1009(2010)Aouida, M., et al. J. Biol. Chem. 285(9):6275-6284(2010)Ota, K., et al. Int. J. Gynecol. Pathol. 26(3):334-340(2007)Lal, S., et al. Pharmacogenomics 8(6):567-575(2007)
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