Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC22A16 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86VW1 |
|---|---|
| Clone Names | 110617132 |
| Gene ID | 85413 |
|---|---|
| Other Names | Solute carrier family 22 member 16, Carnitine transporter 2, CT2, Fly-like putative transporter 2, FLIPT2, Flipt 2, Organic cation transporter OKB1, Organic cation/carnitine transporter 6, SLC22A16, OCT6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC22A16 (HGNC:20302) |
|---|---|
| Synonyms | OCT6 |
| Function | Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine (PubMed:12089149, PubMed:20037140). Mediates the partially Na(+)- dependent bidirectional transport of carnitine (PubMed:12089149). May mediate L-carnitine secretion from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa (PubMed:12089149). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis |
| Tissue Location | Expressed in testis and epididymis (at protein level) (PubMed:12384147, PubMed:12089149, PubMed:15963465). Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase (PubMed:17197897). Expressed at lower levels in adult tissues including bone marrow (at protein level) (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in hematopoietic cells, including CD34(+) leukocytes (PubMed:12384147) Expressed in fetal liver (at protein level), brain, lung, kidney, heart, skeletal muscle, spleen and thymus (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in leukemia cells (PubMed:12384147). Abundantly expressed in ovarian cancer clear-cell adenocarcinoma (PubMed:17581421). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Organic ion transporters, such as SLC22A16, transportvarious medically and physiologically important compounds,including pharmaceuticals, toxins, hormones, neurotransmitters, andcellular metabolites. These transporters are also referred to asamphiphilic solute facilitators (ASFs).
References
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Bray, J., et al. Br. J. Cancer 102(6):1003-1009(2010)Aouida, M., et al. J. Biol. Chem. 285(9):6275-6284(2010)Ota, K., et al. Int. J. Gynecol. Pathol. 26(3):334-340(2007)Lal, S., et al. Pharmacogenomics 8(6):567-575(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
