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SAMHD1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y3Z3
Clone Names 110617285
Peptide ID 110617285
Additional Information
Gene ID 25939
Other Names Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, 315-, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1, SAMHD1, MOP5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAMHD1
Synonyms MOP5
Function Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Cellular Location Nucleus
Tissue Location Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus
Research Areas
Citations (0)

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Background

This gene may play a role in regulation of the innateimmune response. The encoded protein is upregulated in response toviral infection and may be involved in mediation of tumor necrosisfactor-alpha proinflammatory responses. Mutations in this gene havebeen associated with Aicardi-Goutieres syndrome. [provided byRefSeq].

References

Tomkova, H., et al. Eur J Dermatol 20(3):411-413(2010)Dale, R.C., et al. Am. J. Med. Genet. A 152A (4), 938-942 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Rice, G.I., et al. Nat. Genet. 41(7):829-832(2009)Liao, W., et al. Proteomics 8(13):2640-2650(2008)

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$ 80.00
Cat# BP17570c
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