|Other Names||ALS2 C-terminal-like protein, ALS2CL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.|
|Cellular Location||Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells|
|Tissue Location||Expressed in heart and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ALS2CL acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
Suzuki-Utsunomiya, K., et al. Biochem. Biophys. Res. Commun. 354(2):491-497(2007)Hadano, S., et al. FEBS Lett. 575 (1-3), 64-70 (2004) :
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