|Other Names||Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2, PPFIA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.|
|Cellular Location||Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface|
|Tissue Location||Expressed only in brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. It has been proposedthat liprins are multivalent proteins that form complex structuresand act as scaffolds for the recruitment and anchoring of LARfamily of tyrosine phosphatases. This protein is most closelyrelated to PPFIA1, a liprin family member known to interact withthe protein phosphatase LAR. The expression of this gene is foundto be downregulated by androgens in a prostate cancer cell line.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Ko, J., et al. J. Biol. Chem. 278(43):42377-42385(2003)Ko, J., et al. J. Neurosci. 23(5):1667-1677(2003)Fujinami, K., et al. Int. J. Mol. Med. 10(2):173-176(2002)Wyszynski, M., et al. Neuron 34(1):39-52(2002)
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