PPFIA2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75334 |
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Clone Names | 110726163 |
Gene ID | 8499 |
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Other Names | Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2, PPFIA2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PPFIA2 |
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Function | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). |
Cellular Location | Cytoplasm. Cell surface. Cell projection, dendritic spine. Note=Colocalizes with PTPRF at the cell surface |
Tissue Location | Expressed only in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. It has been proposedthat liprins are multivalent proteins that form complex structuresand act as scaffolds for the recruitment and anchoring of LARfamily of tyrosine phosphatases. This protein is most closelyrelated to PPFIA1, a liprin family member known to interact withthe protein phosphatase LAR. The expression of this gene is foundto be downregulated by androgens in a prostate cancer cell line.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Ko, J., et al. J. Biol. Chem. 278(43):42377-42385(2003)Ko, J., et al. J. Neurosci. 23(5):1667-1677(2003)Fujinami, K., et al. Int. J. Mol. Med. 10(2):173-176(2002)Wyszynski, M., et al. Neuron 34(1):39-52(2002)
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