|Other Names||G-protein coupled receptor 78, GPR78|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs) contain 7transmembrane domains and transduce extracellular signals throughheterotrimeric G proteins.
Zhu, X., et al. World J. Gastroenterol. 15(39):4958-4961(2009)Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :Jones, P.G., et al. Biochim. Biophys. Acta 1770(6):890-901(2007)Underwood, S.L., et al. Mol. Psychiatry 11(4):384-394(2006)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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