|Other Names||Kelch-like protein 2, Actin-binding protein Mayven, KLHL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity)|
|Tissue Location||Ubiquitous. Detected throughout the brain.|
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Provided below are standard protocols that you may find useful for product applications.
KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Williams, S.K., et al. J. Neurosci. Res. 81(5):622-631(2005)Bu, X., et al. Oncogene 24(14):2398-2409(2005)Soltysik-Espanola, M., et al. Mol. Biol. Cell 10(7):2361-2375(1999)
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