KLHL2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95198 |
---|---|
Clone Names | 110726104 |
Gene ID | 11275 |
---|---|
Other Names | Kelch-like protein 2, Actin-binding protein Mayven, KLHL2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KLHL2 {ECO:0000303|PubMed:23838290, ECO:0000312|HGNC:HGNC:6353} |
---|---|
Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:23838290). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (PubMed:23838290). Plays a role in the reorganization of the actin cytoskeleton (PubMed:10397770). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669). |
Cellular Location | Cytoplasm, cytoskeleton. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8JZP3}. Cell projection. Cell projection, lamellipodium {ECO:0000250|UniProtKB:F1LZF0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8JZP3}. Note=A proportion colocalizes with the actin cytoskeleton (PubMed:10397770). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity) {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770} |
Tissue Location | Ubiquitous. Detected throughout the brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Williams, S.K., et al. J. Neurosci. Res. 81(5):622-631(2005)Bu, X., et al. Oncogene 24(14):2398-2409(2005)Soltysik-Espanola, M., et al. Mol. Biol. Cell 10(7):2361-2375(1999)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.