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PPP1R16B Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96T49
Clone Names 110726166
Peptide ID 110726166
Additional Information
Gene ID 26051
Other Names Protein phosphatase 1 regulatory inhibitor subunit 16B, Ankyrin repeat domain-containing protein 4, CAAX box protein TIMAP, TGF-beta-inhibited membrane-associated protein, hTIMAP, PPP1R16B, ANKRD4, KIAA0823
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP1R16B
Synonyms ANKRD4, KIAA0823
Function Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Cellular Location Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Note=Colocalizes with RPSA/LAMR1 in the cell membrane
Tissue Location Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis
Research Areas
Citations (0)

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The protein encoded by this gene is membrane-associatedand contains five ankyrin repeats, a proteinphosphatase-1-interacting domain, and a carboxy-terminal CAAX boxdomain. Synthesis of the encoded protein is inhibited bytransforming growth factor beta-1. The protein may bind to themembrane through its CAAX box domain and may act as a signalingmolecule through interaction with protein phosphatase-1.Alternatively spliced transcript variants encoding differentisoforms have been identified in this gene.


Csortos, C., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 295 (3), L440-L450 (2008) :Kim, K., et al. Biochem. Biophys. Res. Commun. 338(3):1327-1334(2005)Homma, K., et al. J. Mol. Biol. 343(5):1207-1220(2004)Cao, W., et al. Am. J. Physiol., Cell Physiol. 283 (1), C327-C337 (2002) :Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 80.00
Cat# BP17590c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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