|Other Names||Protein phosphatase 1 regulatory inhibitor subunit 16B, Ankyrin repeat domain-containing protein 4, CAAX box protein TIMAP, TGF-beta-inhibited membrane-associated protein, hTIMAP, PPP1R16B, ANKRD4, KIAA0823|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.|
|Cellular Location||Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Note=Colocalizes with RPSA/LAMR1 in the cell membrane|
|Tissue Location||Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is membrane-associatedand contains five ankyrin repeats, a proteinphosphatase-1-interacting domain, and a carboxy-terminal CAAX boxdomain. Synthesis of the encoded protein is inhibited bytransforming growth factor beta-1. The protein may bind to themembrane through its CAAX box domain and may act as a signalingmolecule through interaction with protein phosphatase-1.Alternatively spliced transcript variants encoding differentisoforms have been identified in this gene.
Csortos, C., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 295 (3), L440-L450 (2008) :Kim, K., et al. Biochem. Biophys. Res. Commun. 338(3):1327-1334(2005)Homma, K., et al. J. Mol. Biol. 343(5):1207-1220(2004)Cao, W., et al. Am. J. Physiol., Cell Physiol. 283 (1), C327-C337 (2002) :Deloukas, P., et al. Nature 414(6866):865-871(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.