RAB20 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NX57 |
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Clone Names | 110726178 |
Gene ID | 55647 |
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Other Names | Ras-related protein Rab-20, RAB20 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RAB20 |
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Function | Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. |
Cellular Location | Golgi apparatus. Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211) {ECO:0000250|UniProtKB:P35295, ECO:0000269|PubMed:21255211} |
Tissue Location | Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
RAB20 plays a role in apical endocytosis/recycling.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Das Sarma, J., et al. Cell Commun. Adhes. 15(1):65-74(2008)Amillet, J.M., et al. Hum. Pathol. 37(3):256-263(2006)Pereira-Leal, J.B., et al. J. Mol. Biol. 313(4):889-901(2001)Lutcke, A., et al. J. Cell. Sci. 107 (PT 12), 3437-3448 (1994) :
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