|Other Names||Ras-related protein Rab-20, RAB20|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.|
|Cellular Location||Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity) Recruited to phagosomes containing S.aureus or M.tuberculosis|
|Tissue Location||Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
RAB20 plays a role in apical endocytosis/recycling.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Das Sarma, J., et al. Cell Commun. Adhes. 15(1):65-74(2008)Amillet, J.M., et al. Hum. Pathol. 37(3):256-263(2006)Pereira-Leal, J.B., et al. J. Mol. Biol. 313(4):889-901(2001)Lutcke, A., et al. J. Cell. Sci. 107 (PT 12), 3437-3448 (1994) :
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