|Other Names||Ras-related protein Rab-26, RAB26|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.|
|Cellular Location||Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.|
|Tissue Location||Predominantly expressed in brain.|
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Members of the RAB protein family, including RAB26, areimportant regulators of vesicular fusion and trafficking. The RABfamily of small G proteins regulates intercellular vesicletrafficking, including exocytosis, endocytosis, and recycling(summary by Seki et al., 2000 [PubMed 11043516]).[supplied byOMIM].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Tian, X., et al. Mol. Cell. Biol. 30(5):1269-1284(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Swick, L., et al. J. Neurochem. 97(5):1447-1455(2006)Martin, J., et al. Nature 432(7020):988-994(2004)
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