|Other Names||Tumor necrosis factor receptor superfamily member 19L, Receptor expressed in lymphoid tissues, RELT, TNFRSF19L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates activation of NF-kappa-B. May play a role in T- cell activation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cytoplasm|
|Tissue Location||Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is especially abundant inhematologic tissues. It has been shown to activate the NF-kappaBpathway and selectively bind TNF receptor-associated factor 1(TRAF1). This receptor is capable of stimulating T-cellproliferation in the presence of CD3 signaling, which suggests itsregulatory role in immune response. Two alternatively splicedtranscript variants of this gene encoding the same protein havebeen reported.
Cusick, J.K., et al. Cell. Immunol. 261(1):1-8(2010)Polek, T.C., et al. Biochem. Biophys. Res. Commun. 349(3):1016-1024(2006)Bossen, C., et al. J. Biol. Chem. 281(20):13964-13971(2006)Cusick, J.K., et al. Biochem. Biophys. Res. Commun. 340(2):535-543(2006)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
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