SLC43A1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75387 |
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Clone Names | 110726221 |
Gene ID | 8501 |
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Other Names | Large neutral amino acids transporter small subunit 3, L-type amino acid transporter 3, Prostate cancer overexpressed gene 1 protein, Solute carrier family 43 member 1, SLC43A1 {ECO:0000312|EMBL:AAH016391} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC43A1 {ECO:0000312|EMBL:AAH01639.1} |
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Function | Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein. Note=Located in the apical plasma membrane of the podocyte foot processes (PubMed:19443642). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q8BSM7, ECO:0000269|PubMed:19443642} |
Tissue Location | Ubiquitously expressed in fetus and adult (PubMed:9722952). Highest expression in adult pancreas, liver, skeletal muscle (PubMed:9722952, PubMed:12930836). In fetus, highest expression in liver and lower levels in kidney, and lung (PubMed:12930836) Exclusively expressed in the glomeruli along the glomerular capillary walls (PubMed:19443642). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC43A1 belongs to the system L family of plasma membranecarrier proteins that transports large neutral amino acids (Babu etal., 2003 [PubMed 12930836]).
References
Broer, S. Physiol. Rev. 88(1):249-286(2008)Babu, E., et al. J. Biol. Chem. 278(44):43838-43845(2003)Skotheim, R.I., et al. Cancer Res. 62(8):2359-2364(2002)Cole, K.A., et al. Genomics 51(2):282-287(1998)Chuaqui, R.F., et al. Urology 50(2):302-307(1997)
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