|Other Names||Sorting nexin-33, SH3 and PX domain-containing protein 3, SNX33, SH3PX3, SH3PXD3C, SNX30|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||SH3PX3, SH3PXD3C, SNX30|
|Function||Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.|
|Cellular Location||Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941).|
|Tissue Location||Detected in heart and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
SNX33 belongs to the sorting nexin family. It contains a PX (phox homology) domain and an SH3 domain. It interacts with ADAM15.
Kleino, I., et al. J. Cell. Biochem. 108(4):877-885(2009)Zhang, J., et al. J. Biol. Chem. 284(32):21659-21669(2009)Voss, M., et al. BMC Immunol. 10, 53 (2009) :Heiseke, A., et al. Traffic 9(7):1116-1129(2008)Schobel, S., et al. J. Biol. Chem. 283(21):14257-14268(2008)
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