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SPO11 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5K1
Clone Names 110726230
Peptide ID 110726230
Additional Information
Gene ID 23626
Other Names Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35, SPO11
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPO11
Function Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).
Cellular Location Nucleus.
Tissue Location Highly expressed in testis.
Research Areas
Citations (0)

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Meiotic recombination and chromosome segregation requirethe formation of double-strand breaks (DSBs) in paired chromosomehomologs. During meiosis in yeast, a meiotic recombination proteinis covalently-linked to the 5' end of DSBs and is essential for theformation of DSBs. The protein encoded by this gene is similar insequence and conserved features to the yeast meiotic recombinationprotein. The encoded protein belongs to the TOP6A protein family.Several transcript variants encoding different isoforms have beenfound for this gene, but the full-length nature of only two of themhave been described.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Mandon-Pepin, B., et al. Eur. J. Endocrinol. 158(1):107-115(2008)Christensen, G.L., et al. Fertil. Steril. 84(3):758-760(2005)Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 80.00
Cat# BP17609b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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