|Other Names||Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35, SPO11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Meiotic recombination and chromosome segregation requirethe formation of double-strand breaks (DSBs) in paired chromosomehomologs. During meiosis in yeast, a meiotic recombination proteinis covalently-linked to the 5' end of DSBs and is essential for theformation of DSBs. The protein encoded by this gene is similar insequence and conserved features to the yeast meiotic recombinationprotein. The encoded protein belongs to the TOP6A protein family.Several transcript variants encoding different isoforms have beenfound for this gene, but the full-length nature of only two of themhave been described.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)Mandon-Pepin, B., et al. Eur. J. Endocrinol. 158(1):107-115(2008)Christensen, G.L., et al. Fertil. Steril. 84(3):758-760(2005)Deloukas, P., et al. Nature 414(6866):865-871(2001)
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