SRPR Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P08240 |
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Clone Names | 110726232 |
Gene ID | 6734 |
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Other Names | Signal recognition particle receptor subunit alpha, SR-alpha, Docking protein alpha, DP-alpha, SRPR |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SRPRA (HGNC:11307) |
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Synonyms | SRPR |
Function | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32916}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32916}; Cytoplasmic side {ECO:0000250|UniProtKB:P32916}. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. {ECO:0000250|UniProtKB:P32916} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The gene encodes a subunit of the endoplasmic reticulumsignal recognition particle receptor that, in conjunction with thesignal recognition particle, is involved in the targeting andtranslocation of signal sequence tagged secretory and membraneproteins across the endoplasmic reticulum. Alternative splicingresults in multiple transcript variants.
References
Janin, N., et al. Hum. Genet. 88(5):583-585(1992)Hortsch, M., et al. Biochem. Biophys. Res. Commun. 150(1):111-117(1988)Hortsch, M., et al. Nucleic Acids Res. 16(1):361-362(1988)Tajima, S., et al. J. Cell Biol. 103(4):1167-1178(1986)
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