|Other Names||Ankyrin repeat and SOCS box protein 10, ASB-10, ASB10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Cellular Location||Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells|
|Tissue Location||Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.|
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The protein encoded by this gene is a member of theankyrin repeat and SOCS box-containing (ASB) family of proteins.The SOCS box serves to couple suppressor of cytokine signaling(SOCS) proteins and their binding partners with the elongin B and Ccomplex, possibly targeting them for degradation. Multiplealternatively spliced transcript variants have been described forthis gene.
Kohroki, J., et al. FEBS Lett. 579(30):6796-6802(2005)Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
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