|Other Names||Cysteine-rich secretory protein 1, CRISP-1, AEG-like protein, ARP, Acidic epididymal glycoprotein homolog, CRISP1, AEGL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in sperm-egg fusion and maturation.|
|Cellular Location||Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head|
|Tissue Location||Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma|
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Provided below are standard protocols that you may find useful for product applications.
Fertilization consists of a sequence of specific cell-cellinteractions culminating in the fusion of the sperm and egg plasmamembranes. Recognition, binding, and fusion occur through theinteraction of complementary molecules that are localized tospecific domains of the sperm and egg plasma membranes. In thesperm, the postacrosomal region or equatorial segment is involvedin sperm-egg plasma membrane fusion. The protein encoded by thisgene is a member of the cysteine-rich secretory protein (CRISP)family. This protein is expressed in the epididymis, is secretedinto the epididymal lumen, and binds to the postacrosomal region ofthe sperm head where it plays a role at fertilization in sperm-eggfusion through complementary sites localized on the egg surface.Two isoforms are encoded by transcript variants of this gene.
Mungall, A.J., et al. Nature 425(6960):805-811(2003)Evans, J.P. Hum. Reprod. Update 8(4):297-311(2002)Cuasnicu, P.S., et al. Arch. Med. Res. 32(6):614-618(2001)Cohen, D.J., et al. Biol. Reprod. 65(4):1000-1005(2001)Kirchhoff, C. Rev. Reprod. 3(2):86-95(1998)
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