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PDZD3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86UT5
Clone Names 110808236
Peptide ID 110808236
Additional Information
Gene ID 79849
Other Names Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDZD3
Function Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
Cellular Location Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells
Tissue Location Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
Research Areas
Citations (0)

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Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) producescGMP following the binding of either endogenous ligands orheat-stable enterotoxins secreted by E. coli and other entericbacteria. Activation of GCC initiates a signaling cascade thatleads to phosphorylation of the cystic fibrosis transmembraneconductance regulator (CFTR; MIM 602421), followed by a net effluxof ions and water into the intestinal lumen. IKEPP is a regulatoryprotein that associates with GCC and regulates the amount of cGMPproduced following receptor stimulation (Scott et al., 2002 [PubMed11950846]).


Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) :Kato, Y., et al. Mol. Pharmacol. 67(3):734-743(2005)Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302(3):454-461(2003)Scott, R.O., et al. J. Biol. Chem. 277(25):22934-22941(2002)

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$ 80.00
Cat# BP17639c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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