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PDZD3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86UT5 |
|---|---|
| Clone Names | 110808236 |
| Gene ID | 79849 |
|---|---|
| Other Names | Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NHERF4 |
|---|---|
| Synonyms | IKEPP, PDZD3, PDZK2 |
| Function | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451). |
| Tissue Location | Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) producescGMP following the binding of either endogenous ligands orheat-stable enterotoxins secreted by E. coli and other entericbacteria. Activation of GCC initiates a signaling cascade thatleads to phosphorylation of the cystic fibrosis transmembraneconductance regulator (CFTR; MIM 602421), followed by a net effluxof ions and water into the intestinal lumen. IKEPP is a regulatoryprotein that associates with GCC and regulates the amount of cGMPproduced following receptor stimulation (Scott et al., 2002 [PubMed11950846]).
References
Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) :Kato, Y., et al. Mol. Pharmacol. 67(3):734-743(2005)Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302(3):454-461(2003)Scott, R.O., et al. J. Biol. Chem. 277(25):22934-22941(2002)
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