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PLD4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96BZ4 |
|---|---|
| Other Accession | NP_620145.2 |
| Clone Names | 110808240 |
| Gene ID | 122618 |
|---|---|
| Other Names | Phospholipase D4, PLD 4, Choline phosphatase 4, Phosphatidylcholine-hydrolyzing phospholipase D4, PLD4, C14orf175 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLD4 |
|---|---|
| Synonyms | C14orf175 |
| Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Nucleus {ECO:0000250|UniProtKB:Q8BG07}. Early endosome {ECO:0000250|UniProtKB:Q8BG07}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8BG07}. Note=Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes {ECO:0000250|UniProtKB:Q8BG07} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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