|Other Names||HAUS augmin-like complex subunit 7, 26S proteasome-associated UCH37-interacting protein 1, UCHL5-interacting protein, X-linked protein STS1769, HAUS7, UCHL5IP, UIP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules|
|Tissue Location||Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein identified by interaction withubiquitin C-terminal hydrolase 37, which functions to editpolyubiquitin chains on ubiquitinated substrates. This protein is asubunit of the multisubunit augmin complex, which regulatescentrosome and mitotic spindle integrity, and is necessary for thecompletion of cytokinesis.
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)Chen, M.J., et al. Nucleic Acids Res. 35(8):2682-2694(2007)Hahn, Y., et al. Hum. Genet. 119 (1-2), 169-178 (2006) :
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