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SCO2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43819 |
|---|---|
| Clone Names | 100623249 |
| Gene ID | 9997 |
|---|---|
| Other Names | Protein SCO2 homolog, mitochondrial, SCO2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SCO2 |
|---|---|
| Function | Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203). Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytochrome c oxidase (COX) catalyzes the transfer ofelectrons from cytochrome c to molecular oxygen, which helps tomaintain the proton gradient across the inner mitochondrialmembrane that is necessary for aerobic ATP production. Human COX isa multimeric protein complex that requires several assemblyfactors; this gene encodes one of the COX asembly factors. Theencoded protein is a metallochaperone that is involved in thebiogenesis of cytochrome c oxidase subunit II. Mutations in thisgene are associated with fatal infantile encephalocardiomyopathy.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Foltopoulou, P.F., et al. Biochim. Biophys. Acta 1802(6):497-508(2010)Pronicki, M., et al. Eur. J. Paediatr. Neurol. 14(3):253-260(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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