|Other Names||Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, SLC1A2, EAAT2, GLT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of solutetransporter proteins. The membrane-bound protein is the principaltransporter that clears the excitatory neurotransmitter glutamatefrom the extracellular space at synapses in the central nervoussystem. Glutamate clearance is necessary for proper synapticactivation and to prevent neuronal damage from excessive activationof glutamate receptors. Mutations in and decreased expression ofthis protein are associated with amyotrophic lateral sclerosis.Alternatively spliced transcript variants of this gene have beenidentified.
Gebhardt, F.M., et al. J. Biol. Chem. 285(41):31313-31324(2010)Tian, G., et al. J. Neurochem. 113(4):978-989(2010)Nagai, Y., et al. Neurosci. Lett. 463(3):223-227(2009)Sasaki, K., et al. FEBS Lett. 583(13):2194-2200(2009)Gehring, E.M., et al. Cell. Physiol. Biochem. 24 (5-6), 361-368 (2009) :
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