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SLC1A2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P43004
Clone Names 100507223
Peptide ID 100507223
Additional Information
Gene ID 6506
Other Names Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, SLC1A2, EAAT2, GLT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC1A2
Synonyms EAAT2, GLT1
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

This gene encodes a member of a family of solutetransporter proteins. The membrane-bound protein is the principaltransporter that clears the excitatory neurotransmitter glutamatefrom the extracellular space at synapses in the central nervoussystem. Glutamate clearance is necessary for proper synapticactivation and to prevent neuronal damage from excessive activationof glutamate receptors. Mutations in and decreased expression ofthis protein are associated with amyotrophic lateral sclerosis.Alternatively spliced transcript variants of this gene have beenidentified.

References

Gebhardt, F.M., et al. J. Biol. Chem. 285(41):31313-31324(2010)Tian, G., et al. J. Neurochem. 113(4):978-989(2010)Nagai, Y., et al. Neurosci. Lett. 463(3):223-227(2009)Sasaki, K., et al. FEBS Lett. 583(13):2194-2200(2009)Gehring, E.M., et al. Cell. Physiol. Biochem. 24 (5-6), 361-368 (2009) :

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$ 80.00
Cat# BP17647a
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