|Other Names||Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2, SLC1A2, EAAT2, GLT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of solutetransporter proteins. The membrane-bound protein is the principaltransporter that clears the excitatory neurotransmitter glutamatefrom the extracellular space at synapses in the central nervoussystem. Glutamate clearance is necessary for proper synapticactivation and to prevent neuronal damage from excessive activationof glutamate receptors. Mutations in and decreased expression ofthis protein are associated with amyotrophic lateral sclerosis.Alternatively spliced transcript variants of this gene have beenidentified.
Gebhardt, F.M., et al. J. Biol. Chem. 285(41):31313-31324(2010)Tian, G., et al. J. Neurochem. 113(4):978-989(2010)Nagai, Y., et al. Neurosci. Lett. 463(3):223-227(2009)Sasaki, K., et al. FEBS Lett. 583(13):2194-2200(2009)Gehring, E.M., et al. Cell. Physiol. Biochem. 24 (5-6), 361-368 (2009) :
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