|Other Names||E3 ubiquitin-protein ligase RNF14, 632-, Androgen receptor-associated protein 54, HFB30, RING finger protein 14, Triad2 protein, RNF14, ARA54|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed.|
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The protein encoded by this gene contains a RING zincfinger, a motif known to be involved in protein-proteininteractions. This protein interacts with androgen receptor (AR)and may function as a coactivator that induces AR target geneexpression in prostate. A dominant negative mutant of this gene hasbeen demonstrated to inhibit the AR-mediated growth of prostatecancer. This protein also interacts with class IIIubiquitin-conjugating enzymes (E2s) and may act as aubiquitin-ligase (E3) in the ubiquitination of certain nuclearproteins. Five alternatively spliced transcript variants encodingtwo distinct isoforms have been reported.
Xu, K., et al. Cancer Cell 15(4):270-282(2009)Lan, K.C., et al. Fertil. Steril. 89 (5 SUPPL), 1397-1405 (2008) :Kikuchi, H., et al. Carcinogenesis 28(8):1752-1758(2007)Yang, Z., et al. Endocrinology 148(3):1340-1349(2007)Yang, Z., et al. Mol. Endocrinol. 21(2):343-358(2007)
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