|Other Names||Secreted Ly-6/uPAR-related protein 1, SLURP-1, ARS component B, ARS(component B)-81/S, Anti-neoplastic urinary protein, ANUP, SLURP1, ARS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU- dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).|
|Tissue Location||Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine|
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The protein encoded by this gene is a member of theLy6/uPAR family but lacks a GPI-anchoring signal sequence. It isthought that this secreted protein contains antitumor activity.Mutations in this gene have been associated with Mal de Meleda, arare autosomal recessive skin disorder. This gene maps to the samechromosomal region as several members of the Ly6/uPAR family ofglycoprotein receptors.
Chernyavsky, A.I., et al. Am. J. Physiol., Cell Physiol. 299 (5), C903-C911 (2010) :Narumoto, O., et al. Biochem. Biophys. Res. Commun. 398(4):713-718(2010)Phan, T.C., et al. J. Periodont. Res. 45(3):331-336(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Wajid, M., et al. J. Dermatol. Sci. 56(1):27-32(2009)
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