|Other Names||ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir22, IRK-2, Inward rectifier K(+) channel Kir22v, Potassium channel, inwardly rectifying subfamily J member 12, KCNJ12, IRK2, KCNJN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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This gene encodes an inwardly rectifying K+ channel whichmay be blocked by divalent cations. This protein is thought to beone of multiple inwardly rectifying channels which contribute tothe cardiac inward rectifier current (IK1). The gene is locatedwithin the Smith-Magenis syndrome region on chromosome 17.
Collins, A., et al. J. Cell. Physiol. 219(1):8-13(2009)Ji, W., et al. Nat. Genet. 40(5):592-599(2008)Panama, B.K., et al. J. Physiol. (Lond.) 571 (PT 2), 287-302 (2006) :Kiesecker, C., et al. J. Mol. Med. 84(1):46-56(2006)Kubo, Y., et al. Pharmacol. Rev. 57(4):509-526(2005)
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