INF2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q27J81 |
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Clone Names | 110617096 |
Gene ID | 64423 |
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Other Names | Inverted formin-2, HBEBP2-binding protein C, INF2, C14orf151, C14orf173 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | INF2 |
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Synonyms | C14orf151, C14orf173 |
Function | Severs actin filaments and accelerates their polymerization and depolymerization. |
Cellular Location | Cytoplasm, perinuclear region |
Tissue Location | Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene represents a member of the formin family ofproteins. It is considered a diaphanous formin due to the presenceof a diaphanous inhibitory domain located at the N-terminus of theencoded protein. Studies of a similar mouse protein indicate thatthe protein encoded by this locus may function in polymerizationand depolymerization of actin filaments. Mutations at this locushave been associated with focal segmental glomerulosclerosis 5.
References
Brown, E.J., et al. Nat. Genet. 42(1):72-76(2010)Chhabra, E.S., et al. J. Biol. Chem. 281(36):26754-26767(2006)Bindschadler, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(41):14685-14686(2004)
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