|Other Names||Inverted formin-2, HBEBP2-binding protein C, INF2, C14orf151, C14orf173|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Severs actin filaments and accelerates their polymerization and depolymerization.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene represents a member of the formin family ofproteins. It is considered a diaphanous formin due to the presenceof a diaphanous inhibitory domain located at the N-terminus of theencoded protein. Studies of a similar mouse protein indicate thatthe protein encoded by this locus may function in polymerizationand depolymerization of actin filaments. Mutations at this locushave been associated with focal segmental glomerulosclerosis 5.
Brown, E.J., et al. Nat. Genet. 42(1):72-76(2010)Chhabra, E.S., et al. J. Biol. Chem. 281(36):26754-26767(2006)Bindschadler, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(41):14685-14686(2004)
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