LPHN3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HAR2 |
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Clone Names | 110617234 |
Gene ID | 23284 |
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Other Names | Latrophilin-3, Calcium-independent alpha-latrotoxin receptor 3, CIRL-3, Lectomedin-3, LPHN3, KIAA0768, LEC3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ADGRL3 (HGNC:20974) |
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Function | Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q80TS3}. Cell junction {ECO:0000250|UniProtKB:Q80TS3} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the latrophilin subfamily ofG-protein coupled receptors (GPCR). Latrophilins may function inboth cell adhesion and signal transduction. In experiments withnon-human species, endogenous proteolytic cleavage within acysteine-rich GPS (G-protein-coupled-receptor proteolysis site)domain resulted in two subunits (a large extracellular N-terminalcell adhesion subunit and a subunit with substantial similarity tothe secretin/calcitonin family of GPCRs) being non-covalently boundat the cell membrane.
References
Arcos-Burgos, M., et al. Mol. Psychiatry 15(11):1053-1066(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Kasperaviciute, D., et al. Brain 133 (PT 7), 2136-2147 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
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