|Other Names||Latrophilin-3, Calcium-independent alpha-latrotoxin receptor 3, CIRL-3, Lectomedin-3, LPHN3, KIAA0768, LEC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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This gene encodes a member of the latrophilin subfamily ofG-protein coupled receptors (GPCR). Latrophilins may function inboth cell adhesion and signal transduction. In experiments withnon-human species, endogenous proteolytic cleavage within acysteine-rich GPS (G-protein-coupled-receptor proteolysis site)domain resulted in two subunits (a large extracellular N-terminalcell adhesion subunit and a subunit with substantial similarity tothe secretin/calcitonin family of GPCRs) being non-covalently boundat the cell membrane.
Arcos-Burgos, M., et al. Mol. Psychiatry 15(11):1053-1066(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Kasperaviciute, D., et al. Brain 133 (PT 7), 2136-2147 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
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