DACH1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UI36 |
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Clone Names | 100623220 |
Gene ID | 1602 |
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Other Names | Dachshund homolog 1, Dach1, DACH1, DACH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DACH1 |
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Synonyms | DACH |
Function | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen |
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Background
This gene encodes a chromatin-associated protein thatassociates with other DNA-binding transcription factors to regulategene expression and cell fate determination during development. Theprotein contains a Ski domain that is highly conserved fromDrosophila to human. Expression of this gene is lost in some formsof metastatic cancer, and is correlated with poor prognosis.Multiple transcript variants encoding different isoforms have beenfound for this gene.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Zhou, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6864-6869(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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