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DACH1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UI36
Clone Names 100623220
Peptide ID 100623220
Additional Information
Gene ID 1602
Other Names Dachshund homolog 1, Dach1, DACH1, DACH
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DACH1
Synonyms DACH
Function Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
Cellular Location Nucleus.
Tissue Location Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen
Research Areas
Citations (0)

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This gene encodes a chromatin-associated protein thatassociates with other DNA-binding transcription factors to regulategene expression and cell fate determination during development. Theprotein contains a Ski domain that is highly conserved fromDrosophila to human. Expression of this gene is lost in some formsof metastatic cancer, and is correlated with poor prognosis.Multiple transcript variants encoding different isoforms have beenfound for this gene.


Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Zhou, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6864-6869(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP17662c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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