|Other Names||Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC2, KIAA0862|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.|
|Cellular Location||Cytoplasm. Nucleus Note=Translocates from cytoplasm to nucleus upon growth factor stimulation|
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This gene encodes a protein that consists almost entirelyof leucine-rich repeats, a domain implicated in protein-proteininteractions. The protein may function as a scaffold linking RAS todownstream signal transducers in the RAS/ERK MAP kinase signalingcascade. Mutations in this gene have been associated withNoonan-like syndrome with loose anagen hair.
Matsunaga-Udagawa, R., et al. J. Biol. Chem. 285(10):7818-7826(2010)Yoshiki, S., et al. Mol. Biol. Cell 21(6):1088-1096(2010)Flotho, C., et al. Blood 115 (4), 913 (2010) :Cordeddu, V., et al. Nat. Genet. 41(9):1022-1026(2009)Rodriguez-Viciana, P., et al. Mol. Cell 22(2):217-230(2006)
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