|Other Names||Sin3 histone deacetylase corepressor complex component SDS3, 45 kDa Sin3-associated polypeptide, Suppressor of defective silencing 3 protein homolog, SUDS3, SAP45, SDS3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.|
|Tissue Location||Expressed in various cancer cell ines.|
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Provided below are standard protocols that you may find useful for product applications.
SDS3 is a subunit of the histone deacetylase (see HDAC1;MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex(Fleischer et al., 2003 [PubMed 12724404]).
Silveira, A.C., et al. Cancer Lett. 276(1):32-37(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Hurst, D.R., et al. Biochem. Biophys. Res. Commun. 348(4):1429-1435(2006)Fleischer, T.C., et al. Mol. Cell. Biol. 23(10):3456-3467(2003)
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