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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ZFP36L2 Antibody (Center) Blocking Peptide   

ZFP36L2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P47974
Clone Names 110717221
Peptide ID 110717221
Additional Information
Gene ID 678
Other Names Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2, Butyrate response factor 2, EGF-response factor 2, ERF-2, Protein TIS11D, ZFP36L2, BRF2, ERF2, RNF162C, TIS11D
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFP36L2
Synonyms BRF2, ERF2, RNF162C, TIS11D
Function mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Research Areas
Citations (0)

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This gene is a member of the TIS11 family of earlyresponse genes. Family members are induced by various agonists suchas the phorbol ester TPA and the polypeptide mitogen EGF. Theencoded protein contains a distinguishing putative zinc fingerdomain with a repeating cys-his motif. This putative nucleartranscription factor most likely functions in regulating theresponse to growth factors.


Morgan, B.R., et al. Protein Sci. 19(6):1222-1234(2010)Jackson, R.S. II, et al. Cell Cycle 5(24):2889-2893(2006)Hudson, B.P., et al. Nat. Struct. Mol. Biol. 11(3):257-264(2004)Blackshear, P.J., et al. Prog. Nucleic Acid Res. Mol. Biol. 75, 43-68 (2003) :Ino, T., et al. Oncogene 11(12):2705-2710(1995)

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$ 80.00
Cat# BP17671c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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