|Other Names||Zinc finger protein 36, C3H1 type-like 2, ZFP36-like 2, Butyrate response factor 2, EGF-response factor 2, ERF-2, Protein TIS11D, ZFP36L2, BRF2, ERF2, RNF162C, TIS11D|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BRF2, ERF2, RNF162C, TIS11D|
|Function||mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the TIS11 family of earlyresponse genes. Family members are induced by various agonists suchas the phorbol ester TPA and the polypeptide mitogen EGF. Theencoded protein contains a distinguishing putative zinc fingerdomain with a repeating cys-his motif. This putative nucleartranscription factor most likely functions in regulating theresponse to growth factors.
Morgan, B.R., et al. Protein Sci. 19(6):1222-1234(2010)Jackson, R.S. II, et al. Cell Cycle 5(24):2889-2893(2006)Hudson, B.P., et al. Nat. Struct. Mol. Biol. 11(3):257-264(2004)Blackshear, P.J., et al. Prog. Nucleic Acid Res. Mol. Biol. 75, 43-68 (2003) :Ino, T., et al. Oncogene 11(12):2705-2710(1995)
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