|Other Names||G-rich sequence factor 1, GRSF-1, GRSF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.|
|Cellular Location||Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cellular proteinthat binds RNAs containing the G-rich element. The protein islocalized in the cytoplasm, and has been shown to stimulatetranslation of viral mRNAs in vitro. Multiple transcript variantsencoding different isoforms have been found for this gene.
Kash, J.C., et al. J. Virol. 76(20):10417-10426(2002)Park, Y.W., et al. Proc. Natl. Acad. Sci. U.S.A. 96(12):6694-6699(1999)Banga, S.S., et al. Cytogenet. Cell Genet. 73(4):295-296(1996)Qian, Z., et al. Nucleic Acids Res. 22(12):2334-2343(1994)
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