|Other Names||Zinc finger protein 224, Bone marrow zinc finger 2, BMZF-2, Zinc finger protein 233, Zinc finger protein 255, Zinc finger protein 27, Zinc finger protein KOX22, ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BMZF2, KOX22, ZNF233, ZNF255, ZNF27|
|Function||May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.|
|Cellular Location||Nucleus Note=Colocalizes with DEPDC1A at the nucleus|
|Tissue Location||Ubiquitous. Mainly expressed in fetal tissues.|
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ZNF224 may be involved in transcriptional regulation as a transcriptional repressor.
Harada, Y., et al. Cancer Res. 70(14):5829-5839(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Shulman, J.M., et al. PLoS ONE 5 (6), E11244 (2010) :Cesaro, E., et al. J. Biol. Chem. 284(47):32321-32330(2009)Iacobazzi, V., et al. Biochem. Biophys. Res. Commun. 386(1):186-191(2009)
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