|Other Names||TBC1 domain family member 10B, Rab27A-GAP-beta, TBC1D10B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.|
|Cellular Location||Cytoplasm. Note=In melanocytes, located at the periphery of cells|
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Provided below are standard protocols that you may find useful for product applications.
Small G proteins of the RAB family (see MIM 179508)function in intracellular vesicle trafficking by switching from theGTP-bound state to the GDP-bound state with the assistance ofguanine nucleotide exchange factors (GEFs; see MIM 609700) andGTPase-activating proteins (GAPs). TBC1D10B functions as a GAP forseveral proteins of the Rab family (Ishibashi et al., 2009 [PubMed19077034]).
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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