|Other Names||Uroplakin-3b, UP3b, Uroplakin IIIb, UPIIIb, p35, UPK3B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).|
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UPK3B is a minor component of the apical plaques ofmammalian urothelium that binds and dimerizes with uroplakin-1b(UPK1B; MIM 602380), one of the major conserved urothelium membraneproteins. The other major conserved integral membrane proteins ofurothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), andUPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[suppliedby OMIM].
Foot, N.J., et al. Blood 112(10):4268-4275(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Garcia-Espana, A., et al. Mol. Phylogenet. Evol. 41(2):355-367(2006)Deng, F.M., et al. J. Cell Biol. 159(4):685-694(2002)
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