|Other Names||C-type lectin domain family 9 member A, CLEC9A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
CLEC9A is a group V C-type lectin-like receptor (CTLR)that functions as an activation receptor and is expressed onmyeloid lineage cells (Huysamen et al., 2008 [PubMed18408006]).
Poulin, L.F., et al. J. Exp. Med. 207(6):1261-1271(2010)Sancho, D., et al. Nature 458(7240):899-903(2009)Caminschi, I., et al. Blood 112(8):3264-3273(2008)Huysamen, C., et al. J. Biol. Chem. 283(24):16693-16701(2008)Sancho, D., et al. J. Clin. Invest. 118(6):2098-2110(2008)
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