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CLEC9A Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UXN8
Clone Names 110729062
Additional Information
Gene ID 283420
Other Names C-type lectin domain family 9 member A, CLEC9A
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC9A
Function Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Cellular Location Membrane; Single- pass type II membrane protein
Tissue Location In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
Research Areas
Citations (0)
citation

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Background

CLEC9A is a group V C-type lectin-like receptor (CTLR)that functions as an activation receptor and is expressed onmyeloid lineage cells (Huysamen et al., 2008 [PubMed18408006]).

References

Poulin, L.F., et al. J. Exp. Med. 207(6):1261-1271(2010)Sancho, D., et al. Nature 458(7240):899-903(2009)Caminschi, I., et al. Blood 112(8):3264-3273(2008)Huysamen, C., et al. J. Biol. Chem. 283(24):16693-16701(2008)Sancho, D., et al. J. Clin. Invest. 118(6):2098-2110(2008)

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$ 277.78
Cat# BP17684c
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