MPZL2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O60487 |
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Clone Names | 110729142 |
Gene ID | 10205 |
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Other Names | Myelin protein zero-like protein 2, Epithelial V-like antigen 1, MPZL2, EVA, EVA1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MPZL2 |
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Synonyms | EVA {ECO:0000303|PubMed:9585423}, EVA1 |
Function | Mediates homophilic cell-cell adhesion. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Widely expressed. In fetal tissues, highest expression in the inner ear. In adult tissues, highest levels in thymus and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thymus development depends on a complex series ofinteractions between thymocytes and the stromal component of theorgan. Epithelial V-like antigen (EVA) is expressed in thymusepithelium and strongly downregulated by thymocyte developmentalprogression. This gene is expressed in the thymus and in severalepithelial structures early in embryogenesis. It is highlyhomologous to the myelin protein zero and, in thymus-derivedepithelial cell lines, is poorly soluble in nonionic detergents,strongly suggesting an association to the cytoskeleton. Itscapacity to mediate cell adhesion through a homophilic interactionand its selective regulation by T cell maturation might imply theparticipation of EVA in the earliest phases of thymusorganogenesis. The protein bears a characteristic V-type domain andtwo potential N-glycosylation sites in the extracellular domain; aputative serine phosphorylation site for casein kinase 2 is alsopresent in the cytoplasmic tail. Two transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].
References
Kim, H., et al. Pharmacogenomics 10(2):171-179(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Guttinger, M., et al. J. Cell Biol. 141(4):1061-1071(1998)
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