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MPZL2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O60487
Clone Names 110729142
Peptide ID 110729142
Additional Information
Gene ID 10205
Other Names Myelin protein zero-like protein 2, Epithelial V-like antigen 1, MPZL2, EVA, EVA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MPZL2
Synonyms EVA, EVA1
Function Mediates homophilic cell-cell adhesion.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias
Research Areas
Citations (0)

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Thymus development depends on a complex series ofinteractions between thymocytes and the stromal component of theorgan. Epithelial V-like antigen (EVA) is expressed in thymusepithelium and strongly downregulated by thymocyte developmentalprogression. This gene is expressed in the thymus and in severalepithelial structures early in embryogenesis. It is highlyhomologous to the myelin protein zero and, in thymus-derivedepithelial cell lines, is poorly soluble in nonionic detergents,strongly suggesting an association to the cytoskeleton. Itscapacity to mediate cell adhesion through a homophilic interactionand its selective regulation by T cell maturation might imply theparticipation of EVA in the earliest phases of thymusorganogenesis. The protein bears a characteristic V-type domain andtwo potential N-glycosylation sites in the extracellular domain; aputative serine phosphorylation site for casein kinase 2 is alsopresent in the cytoplasmic tail. Two transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].


Kim, H., et al. Pharmacogenomics 10(2):171-179(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Guttinger, M., et al. J. Cell Biol. 141(4):1061-1071(1998)

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$ 80.00
Cat# BP17697c
Availability: In Stock
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