|Other Names||PWWP domain-containing protein MUM1, Mutated melanoma-associated antigen 1, MUM-1, Protein expandere, MUM1, EXPAND1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.|
|Cellular Location||Nucleus. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Huen, M.S., et al. Mol. Cell 37(6):854-864(2010)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Coulie, P.G., et al. Proc. Natl. Acad. Sci. U.S.A. 92(17):7976-7980(1995)
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