OTOP2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q7RTS6 |
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Clone Names | 110729167 |
Gene ID | 92736 |
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Other Names | Otopetrin-2, OTOP2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | OTOP2 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19657} |
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Function | Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.
References
Hurle, B., et al. Hum. Mol. Genet. 12(7):777-789(2003)
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