|Other Names||Sodium- and chloride-dependent GABA transporter 3, GAT-3, Solute carrier family 6 member 11, SLC6A11, GABT3, GAT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Widespread distribution in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Gamma-aminobutyric acid (GABA) is a major inhibitoryneurotransmitter. GABAergic neurotransmission is terminated by theuptake of GABA into the presynaptic terminal and the surroundingastroglial cells by sodium-dependent transporters, such as SLC6A11(Borden et al., 1994 [PubMed 7874447]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Pallo, A., et al. Biochem. Biophys. Res. Commun. 385(2):210-214(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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