|Other Names||Engulfment and cell motility protein 3, ELMO3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to a C.elegans protein that functions in phagocytosis of apoptotic cellsand in cell migration. Other members of this small family ofengulfment and cell motility (ELMO) proteins have been shown tointeract with the dedicator of cyto-kinesis 1 protein to promotephagocytosis and effect cell shape changes.
Coskun, M., et al. J. Cell. Biochem. 109(6):1118-1128(2010)Gumienny, T.L., et al. Cell 107(1):27-41(2001)
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