|Other Names||Male-specific lethal 3 homolog, Male-specific lethal-3 homolog 1, Male-specific lethal-3 protein-like 1, MSL3-like 1, MSL3, MSL3L1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.|
|Tissue Location||Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart|
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This gene encodes a nuclear protein that is similar to theproduct of the Drosophila male-specific lethal-3 gene. TheDrosophila protein plays a critical role in a dosage-compensationpathway, which equalizes X-linked gene expression in males andfemales. Thus, the human protein is thought to play a similarfunction in chromatin remodeling and transcriptional regulation,and it has been found as part of a complex that is responsible forhistone H4 lysine-16 acetylation. This gene can undergo Xinactivation. Alternative splicing results in multiple transcriptvariants. Related pseudogenes have been identified on chromosomes2, 7 and 8.
Smith, E.R., et al. Mol. Cell. Biol. 25(21):9175-9188(2005)Marin, I., et al. Mol. Biol. Evol. 17(8):1240-1250(2000)Prakash, S.K., et al. Genomics 59(1):77-84(1999)
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