|Other Names||Mitochondrial sodium/hydrogen exchanger 9B2, Mitochondrial Na(+)/H(+) exchanger NHA2, Na(+)/H(+) exchanger-like domain-containing protein 2, NHE domain-containing protein 2, Sodium/hydrogen exchanger-like domain-containing protein 2, Solute carrier family 9 subfamily B member 2, SLC9B2, NHA2, NHEDC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity).|
|Cellular Location||Mitochondrion membrane; Multi- pass membrane protein|
|Tissue Location||Detected in red blood cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Sodium hydrogen antiporters, such as NHEDC2, convert theproton motive force established by the respiratory chain or theF1F0 mitochondrial ATPase into sodium gradients that drive otherenergy-requiring processes, transduce environmental signals intocell responses, or function in drug efflux (Xiang et al., 2007[PubMed 18000046]).
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Schushan, M., et al. J. Mol. Biol. 396(5):1181-1196(2010)Fuster, D.G., et al. J. Am. Soc. Nephrol. 19(8):1547-1556(2008)Battaglino, R.A., et al. Bone 42(1):180-192(2008)Xiang, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(47):18677-18681(2007)
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