Register or Login
All
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Peptides   >   Blocking Peptides   >   NTAN1 Antibody (C-term) Blocking Peptide   

NTAN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Primary Accession Q96AB6
Clone Names 110808201
Peptide ID 110808201
Additional Information
Other Names Protein N-terminal asparagine amidohydrolase, 351-, Protein NH2-terminal asparagine amidohydrolase, PNAA, Protein NH2-terminal asparagine deamidase, PNAD, Protein N-terminal Asn amidase, Protein N-terminal asparagine amidase, Protein NTN-amidase, NTAN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTAN1
Function Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N- terminal peptidyl Asn.
Cellular Location Cytoplasm. EMBL; AF092440; AAP97215.1; -; mRNA EMBL; BC017336; AAH17336.1; -; mRNA CCDS; CCDS10558.1; - RefSeq; NP_001257695.1; NM_001270766.1 RefSeq; NP_001257696.1; NM_001270767.1 RefSeq; NP_775745.1; NM_173474.3 UniGene; Hs.592045; - ProteinModelPortal; Q96AB6; - SMR; Q96AB6; - BioGrid; 125835; 2 IntAct; Q96AB6; 1 STRING; 9606.ENSP00000287706; - iPTMnet; Q96AB6; - PhosphoSitePlus; Q96AB6; - DMDM; 37082118; - EPD; Q96AB6; - MaxQB; Q96AB6; - PaxDb; Q96AB6; - PeptideAtlas; Q96AB6; - PRIDE; Q96AB6; - DNASU; 123803; - Ensembl; ENST00000287706; ENSP00000287706; ENSG00000157045 Ensembl; ENST00000620176; ENSP00000484380; ENSG00000275779 GeneID; 123803; - KEGG; hsa:123803; - UCSC; uc002ddd.5; human CTD; 123803; - DisGeNET; 123803; - GeneCards; NTAN1; - HGNC; HGNC:29909; NTAN1 HPA; CAB029997; - HPA; HPA051418; - MIM; 615367; gene neXtProt; NX_Q96AB6; - OpenTargets; ENSG00000157045; - OpenTargets; ENSG00000275779; - PharmGKB; PA134863573; - eggNOG; ENOG410IE4U; Eukaryota eggNOG; ENOG410XW2S; LUCA GeneTree; ENSGT00390000016730; - HOGENOM; HOG000047800; - HOVERGEN; HBG052674; - InParanoid; Q96AB6; - KO; K14662; - OMA; CLAHCDG; - OrthoDB; EOG091G09RF; - PhylomeDB; Q96AB6; - TreeFam; TF325597; - BioCyc; ZFISH:ENSG00000157045-MONOMER; - GenomeRNAi; 123803; - PRO; PR:Q96AB6; - Proteomes; UP000005640; Chromosome 16 Bgee; ENSG00000157045; - CleanEx; HS_NTAN1; - ExpressionAtlas; Q96AB6; baseline and differential Genevisible; Q96AB6; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IEA:Ensembl GO; GO:0008418; F:protein-N-terminal asparagine amidohydrolase activity; IEA:Ensembl GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl GO; GO:0007613; P:memory; IEA:Ensembl InterPro; IPR026750; NTAN1 PANTHER; PTHR12498; PTHR12498; 1 Pfam; PF14736; N_Asn_amidohyd; 1 1: Evidence at protein level; Complete proteome; Cytoplasm; Hydrolase; Polymorphism; Reference proteome INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q28955} CHAIN 2 310 Protein N-terminal asparagine amidohydrolase /FTId=PRO_0000057971 SITE 75 75 Essential for catalytic activity VARIANT 283 283 H -> N (in dbSNP:rs1136001) /FTId=VAR_051244 VARIANT 287 287 S -> P (in dbSNP:rs1135999) /FTId=VAR_051245 MUTAGEN 2 2 P->G: 3-fold reduction in catalytic activity. MUTAGEN 75 75 C->A,S,T: Abolishes catalytic activity CONFLICT 6 6 E -> D (in Ref. 1; AAP97215) CONFLICT 14 14 Q -> R (in Ref. 1; AAP97215) SEQUENCE 310 AA; 34677 MW; C7FE8C550883DFC3 CRC64; MPLLVEGRRV RLPQSAGDLV RAHPPLEERA RLLRGQSVQQ VGPQGLLYVQ QRELAVTSPK DGSISILGSD DATTCHIVVL RHTGNGATCL THCDGTDTKA EVPLIMNSIK SFSDHAQCGR LEVHLVGGFS DDRQLSQKLT HQLLSEFDRQ EDDIHLVTLC VTELNDREEN ENHFPVIYGI AVNIKTAEIY RASFQDRGPE EQLRAARTLA GGPMISIYDA ETEQLRIGPY SWTPFPHVDF WLHQDDKQIL ENLSTSPLAE PPHFVEHIRS TLMFLKKHPS PAHTLFSGNK ALLYKKNEDG LWEKISSPGS
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to
info@abgent.com, and receive a free "I Love Antibodies" mug.

Background

Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position (By similarity).

References

Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Kamdem, L.K., et al. Pharmacogenet. Genomics 18(6):507-514(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Grigoryev, S., et al. J. Biol. Chem. 271(45):28521-28532(1996)

FeedBack
Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at tech@abgent.com.

$ 80.00
Cat# BP17739b
Size:
Quantity:
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanKoreaLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Buy Antibody, Get One  Selected Loading Control Free.
30% off on 400+ Stem Cells Antibodies. PromoCode: <span class=text-red>FLASH19</span>
Terms & Conditions