|Other Names||Transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150, TCERG1, CA150, TAF2S|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.|
|Tissue Location||Detected in brain neurons.|
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This gene encodes a nuclear protein that regulatestranscriptional elongation and pre-mRNA splicing. The encodedprotein interacts with the hyperphosphorylated C-terminal domain ofRNA polymerase II via multiple FF domains, and with the pre-mRNAsplicing factor SF1 via a WW domain. Alternative splicing resultsin multiple transcripts variants encoding different isoforms.
Sanchez-Alvarez, M., et al. J. Biol. Chem. 285(20):15220-15233(2010)Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009)Murphy, J.M., et al. J. Mol. Biol. 393(2):409-424(2009)Lu, M., et al. J. Mol. Biol. 393(2):397-408(2009)Pearson, J.L., et al. J. Biol. Chem. 283(12):7949-7961(2008)
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