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CYLN2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UDT6 |
|---|---|
| Clone Names | 90121090 |
| Gene ID | 7461 |
|---|---|
| Other Names | CAP-Gly domain-containing linker protein 2, Cytoplasmic linker protein 115, CLIP-115, Cytoplasmic linker protein 2, Williams-Beuren syndrome chromosomal region 3 protein, Williams-Beuren syndrome chromosomal region 4 protein, CLIP2, CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLIP2 |
|---|---|
| Synonyms | CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4 |
| Function | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O55156}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z0H8}. Note=Localizes preferentially to the ends of tyrosinated microtubules {ECO:0000250|UniProtKB:Q9Z0H8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family ofcytoplasmic linker proteins, which have been proposed to mediatethe interaction between specific membranous organelles andmicrotubules. This protein was found to associate with bothmicrotubules and an organelle called the dendritic lamellar body.This gene is hemizygously deleted in Williams syndrome, amultisystem developmental disorder caused by the deletion ofcontiguous genes at 7q11.23. Alternative splicing of this genegenerates 2 transcript variants.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Cheng, J., et al. Science 308(5725):1149-1154(2005)Evgrafov, O.V., et al. Nat. Genet. 36(6):602-606(2004)
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