|Other Names||CAP-Gly domain-containing linker protein 2, Cytoplasmic linker protein 115, CLIP-115, Cytoplasmic linker protein 2, Williams-Beuren syndrome chromosomal region 3 protein, Williams-Beuren syndrome chromosomal region 4 protein, CLIP2, CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4|
|Function||Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton|
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The protein encoded by this gene belongs to the family ofcytoplasmic linker proteins, which have been proposed to mediatethe interaction between specific membranous organelles andmicrotubules. This protein was found to associate with bothmicrotubules and an organelle called the dendritic lamellar body.This gene is hemizygously deleted in Williams syndrome, amultisystem developmental disorder caused by the deletion ofcontiguous genes at 7q11.23. Alternative splicing of this genegenerates 2 transcript variants.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Cheng, J., et al. Science 308(5725):1149-1154(2005)Evgrafov, O.V., et al. Nat. Genet. 36(6):602-606(2004)
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