|Other Names||Low-density lipoprotein receptor class A domain-containing protein 4, LDLRAD4, C18orf1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.|
|Cellular Location||Early endosome membrane; Single-pass membrane protein|
|Tissue Location||Expressed in lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
C18orf1 belongs to the PMEPA1 family and contains 1 LDL-receptor class A domain.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Levy, D., et al. Nat. Genet. 41(6):677-687(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Yoshikawa, T., et al. Genomics 47(2):246-257(1998)
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