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AKIR1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H9L7
Clone Names 91113307
Peptide ID 91113307
Additional Information
Gene ID 79647
Other Names Akirin-1, AKIRIN1, C1orf108
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C1orf108
Cellular Location Nucleus.
Tissue Location Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes
Research Areas
Citations (0)

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The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.


Goto, A., et al. Nat. Immunol. 9(1):97-104(2008)

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$ 80.00
Cat# BP17755b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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