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C1orf135 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H7T9 |
|---|---|
| Clone Names | 100111108 |
| Gene ID | 79000 |
|---|---|
| Other Names | Aurora kinase A and ninein-interacting protein, AIBp, AUNIP, C1orf135 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AUNIP {ECO:0000303|PubMed:29042561, ECO:0000312|HGNC:HGNC:28363} |
|---|---|
| Function | DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non- homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670). |
| Cellular Location | Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks (PubMed:29042561). Localizes to the centrosome in interphase and to the spindle pole in metaphase (PubMed:20596670) |
| Tissue Location | Expressed in heart, skeletal muscles, placenta and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Suzuki, Y., et al. Gene 200 (1-2), 149-156 (1997) :
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