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TMEM123 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8N131
Clone Names 100528277
Peptide ID 100528277
Additional Information
Gene ID 114908
Other Names Porimin, Keratinocytes-associated transmembrane protein 3, KCT-3, Pro-oncosis receptor inducing membrane injury, Transmembrane protein 123, TMEM123, KCT3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM123
Synonyms KCT3
Function Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.
Research Areas
Citations (0)

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This gene encodes a highly glycosylated transmembraneprotein with a high content of threonine and serine residues in itsextracellular domain, similar to a broadly defined category ofproteins termed mucins. Exposure of some cell types to anti-PORIMIN(pro-oncosis receptor inducing membrane injury) antibody,crosslinks this protein on the cell surface and induces a type ofcell death termed oncosis. Oncosis is distinct from apoptosis andis characterized by a loss of cell membrane integrity without DNAfragmentation. This gene product is proposed to function as a cellsurface receptor that mediates cell death.


Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Bonkobara, M., et al. Br. J. Dermatol. 148(4):654-664(2003)Dekker, J., et al. Trends Biochem. Sci. 27(3):126-131(2002)Ma, F., et al. Proc. Natl. Acad. Sci. U.S.A. 98(17):9778-9783(2001)Zhang, C., et al. Proc. Natl. Acad. Sci. U.S.A. 95(11):6290-6295(1998)

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$ 80.00
Cat# BP17770b
(40 western blots)
Availability: In Stock
Bulk Size
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