TMEM123 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N131 |
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Clone Names | 100528277 |
Gene ID | 114908 |
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Other Names | Porimin, Keratinocytes-associated transmembrane protein 3, KCT-3, Pro-oncosis receptor inducing membrane injury, Transmembrane protein 123, TMEM123, KCT3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMEM123 |
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Synonyms | KCT3 |
Function | Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Ubiquitous. Not expressed in ovary. Expressed in keratinocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a highly glycosylated transmembraneprotein with a high content of threonine and serine residues in itsextracellular domain, similar to a broadly defined category ofproteins termed mucins. Exposure of some cell types to anti-PORIMIN(pro-oncosis receptor inducing membrane injury) antibody,crosslinks this protein on the cell surface and induces a type ofcell death termed oncosis. Oncosis is distinct from apoptosis andis characterized by a loss of cell membrane integrity without DNAfragmentation. This gene product is proposed to function as a cellsurface receptor that mediates cell death.
References
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Bonkobara, M., et al. Br. J. Dermatol. 148(4):654-664(2003)Dekker, J., et al. Trends Biochem. Sci. 27(3):126-131(2002)Ma, F., et al. Proc. Natl. Acad. Sci. U.S.A. 98(17):9778-9783(2001)Zhang, C., et al. Proc. Natl. Acad. Sci. U.S.A. 95(11):6290-6295(1998)
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