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DCTN3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75935 |
|---|---|
| Clone Names | 101008148 |
| Gene ID | 11258 |
|---|---|
| Other Names | Dynactin subunit 3, Dynactin complex subunit 22 kDa subunit, p22, DCTN3 {ECO:0000312|EMBL:CAG466871}, DCTN22 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DCTN3 {ECO:0000312|EMBL:CAG46687.1} |
|---|---|
| Synonyms | DCTN22 |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells |
| Tissue Location | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the smallest subunit of dynactin, amacromolecular complex consisting of 10 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation,cytokinesis, chromosome movement, nuclear positioning, andaxonogenesis. This subunit, like most other dynactin subunits,exists only as a part of the dynactin complex. It is primarily analpha-helical protein with very little coiled coil, and bindsdirectly to the largest subunit (p150) of dynactin. Alternativesplicing of this gene generates 2 transcript variants. [provided byRefSeq].
References
Lim, J., et al. Cell 125(4):801-814(2006)Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Lehner, B., et al. Genomics 83(1):153-167(2004)Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)
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