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DCTN3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75935
Clone Names 101008148
Peptide ID 101008148
Additional Information
Gene ID 11258
Other Names Dynactin subunit 3, Dynactin complex subunit 22 kDa subunit, p22, DCTN3 {ECO:0000312|EMBL:CAG466871}, DCTN22
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCTN3 {ECO:0000312|EMBL:CAG46687.1}
Synonyms DCTN22
Function Together with dynein may be involved in spindle assembly and cytokinesis.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells
Tissue Location Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain
Research Areas
Citations (0)

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This gene encodes the smallest subunit of dynactin, amacromolecular complex consisting of 10 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation,cytokinesis, chromosome movement, nuclear positioning, andaxonogenesis. This subunit, like most other dynactin subunits,exists only as a part of the dynactin complex. It is primarily analpha-helical protein with very little coiled coil, and bindsdirectly to the largest subunit (p150) of dynactin. Alternativesplicing of this gene generates 2 transcript variants. [provided byRefSeq].


Lim, J., et al. Cell 125(4):801-814(2006)Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Lehner, B., et al. Genomics 83(1):153-167(2004)Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)

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$ 80.00
Cat# BP17778c
Availability: In Stock
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